New TP Sirota/Straka
Vestibular influence on spatial representation in entorhino-hippocampal system
Ability to navigate in space relies on external and internal senses. Importantly, idiothetic vestibular cues provide important information for estimation of the distance and direction that animal travels enabling it to path integrate. The interaction between allocentic representation of space and egocentric path integration at the level of hippocampal representation of space is not understood.
Collaboration of labs of Anton Sirota and Hans Straka combined the expertise of their labs in vestibular system and spatial navigation, respectively, to study the effect of vestibular inputs on hippocampal representation of space in freely moving rodents.
The project will combine use of state of the art electrophysiological and optical recordings of large ensembles of hippocampal neurons, behavioral paradigms aimed to assess navigation abilities and a range of sensory perturbation procedures. Perturbation approach will combine the use of virtual reality system for freely moving rodents with passive linear and angular motion perturbations for interference with head-motion generated visuo-vestibular sensory signals.